Green Earth Institute Co., Ltd.
9212・Growth Market・Services
Business
Green Earth Institute Co., Ltd. is a technology development venture established in 2011 with the aim of commercializing biomanufacturing technology (RITE Bioprocess®) developed over approximately 30 years by the Research Institute of Innovative Technology for the Earth (RITE), a public interest incorporated foundation. With high-efficiency fermentation technology (bioprocess) utilizing Corynebacterium bacteria as its core technology, the company's corporate philosophy is to simultaneously realize a bioeconomy and a circular economy by converting petroleum-derived chemicals into biomass-derived chemicals. Its main customers are NEDO (through commissioned national projects) and partner companies in the chemical, paper, and energy industries both in Japan and overseas, and it provides integrated expertise from research and development through to commercialization for amino acids, biofuels, and bio-resin raw materials, among others. The company listed on the Growth Market of the Tokyo Stock Exchange in December 2021.
Business Model
The Company does not own commercial production facilities itself, and monetizes through four formats: (1) Contract R&D Services (Stage 2: milestone-based revenue), (2) licensing (upfront payment + royalties), (3) proprietary sales (product sales via contracted manufacturing), and (4) Technology Package (bulk provision of microbial strain/process information plus facility design documents). The structure aims to commercialize technologies accumulated in Stage 2 during Stage 3, transitioning to long-term, stable revenue utilizing patent rights and other assets. In FY2025 (ended September 2025), the ratio of sales to NEDO was 38.2% (down from 55.2% in the previous fiscal year), with the ratio to private-sector partners expanding.
Company Strengths
The company holds a proprietary fermentation method that leverages the characteristic of Corynebacterium, which maintains high metabolic activity without proliferating under oxygen-limited conditions. Compared to conventional fermentation methods, it achieves higher raw material efficiency, requires smaller-scale equipment, and enables shorter production times, while being less susceptible to fermentation-inhibiting substances derived from non-edible biomass. Scale-up simulation using CFD and verification equipment with a 3,000L fermentation tank have also been established.
The company has been commissioned for and selected for the Biofoundry Platform project (6 years, total project value of ¥5.4 billion), the Green Innovation Fund project (commissioned in 2023), and the Bio-manufacturing Revolution Promotion Program (1st round: 8 years, total subsidy of approximately ¥1.4 billion; 2nd round: 6 years, total subsidy of approximately ¥300 million). This structure allows national projects to simultaneously support the revenue base and research infrastructure development.
The company has already achieved licensing of five types of amino acids—valine, alanine, aspartic acid, β-alanine, and others—as well as rice-derived next-generation protein, and has also achieved in-house sales of cosmetic-grade ethanol. Starting with a valine licensing agreement with a Chinese company in 2018, the company has built up a track record of commercialization, with Stage 3 revenue for FY2025 (ending September 2025) expanding to ¥172 million (approximately 5 times the previous fiscal year).
ENVALITH's Perspective
Performance Trend
Revenue over the past five fiscal years progressed from ¥503 million → ¥585 million → ¥897 million → ¥1,003 million → ¥1,075 million, maintaining a consistent growth trend. In FY2025 (ended September 2025), the company achieved its first-ever positive ordinary income and net income (net income of ¥127 million). However, in the first half of FY2026 (ending September 2026) (October 2025 to March 2026), revenue was ¥240 million (up 0.1% year on year), operating loss was ¥186 million (versus a loss of ¥133 million in the same period last year), and interim net loss was ¥192 million (versus a loss of ¥134 million in the same period last year), indicating widening losses. This was primarily driven by an increase in SG&A expenses. Given the seasonality of revenue being concentrated in the fourth quarter, achieving the full-year forecast (revenue of ¥1,035 million, net income of ¥146 million) will require substantial revenue recognition in the second half. As an external factor, a foreign exchange loss of ¥5 million was incurred, reflecting the emerging impact of exchange rate fluctuations on overseas transactions.
Growth Strategy
Accelerate commercialization through three forms—licensing, product sales, and Technology Packages—to establish the company's position as a biomanufacturing platformer
Under the biofoundry business commissioned by NEDO (total project scale of ¥54 million, over 6 years), the company is building and operating a platform for developing and demonstrating commercialization processes for biomanufacturing technologies from universities and companies. As of the end of March 2026, construction in progress had reached ¥429 million, indicating that capital investment is now in full swing.
The company continues to advance the Green Innovation Fund Project (bio project scale of ¥1,800 million, over 10 years) aimed at achieving carbon neutrality, as well as the Biomanufacturing Revolution Promotion Project (1st and 2nd rounds). By undertaking these national policy projects, the company simultaneously secures external funding for R&D expenses and accumulates technological expertise.
In FY2025 (ended September 2025), licensing and product sales revenue expanded to ¥172 million (approximately 5 times the previous fiscal year), with sales to China also reaching ¥54 million, indicating progress in commercialization. Through maintaining and expanding the total pipeline of 22 projects (21 in Stage 2 and 1 in Stage 3), the company aims to increase the proportion of revenue from private-sector sources and diversify geographically.
Last updated: July 17, 2026

